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Figure 2 Ahr2-dependent cyp1b1 expression is regulated by Aβ42 and KYNA in the adult zebrafish brain. (A) Normalized expression levels of cyp1b1 in zebrafish telencephalon injected with control vehicle (PBS), KYNA, BNF, Ahr antagonist or Aβ42. (B) In situ hybridization for cyp1b1 in control, BNF, KYNA, antagonist and Aβ42 injected brains. Note the reduction of expression with the Ahr antagonist and Aβ42 and increase with BNF or KYNA. Scale bars equal 50 μm. Statistical calculations and values are provided in Table S1.
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