ZFIN Image: Dahlén et al., 2021, Figure 2

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Figure 2

(A) Co-administration of Tetrahydrocannabinol (THC) and N-methyl-D-aspartate (NMDA) affects the THC-induced behavioral stereotypy in adult zebrafish. (B) At 100 μM NMDA with 1 μM THC the THC-induced Repetition Index (RI), calculated as a mean ± SEM, was not statistically different from the controls (EtOH) (ns p > 0.9999). (C) Nor did NMDA and THC co-administration affect the swimming velocity during exposure. Controls EtOH (0.0015%) (n = 19), 1 μM THC (n = 23), 100 μM NMDA (n = 6), 20 μM NMDA + 1 μM THC (n = 4), 30 μM NMDA + 1 μM THC (n = 4), 40 μM NMDA + 1 μM THC (n = 4) and 100 μM NMDA + 1 μM THC (n = 8). Mean RI values of 20 mM NMDA (n = 4), 30 mM NMDA (n = 4) and 40 mM NMDA (n = 4) were similar to 100 μM NMDA. Values without a letter in common are statistically different to the control condition (p < 0.05, Kruskal–Wallis and Dunn's multiple comparisons). Figure 2A was created with BioRender.com.

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Acknowledgments

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