ZFIN Image: Hoffmann et al., 2021, Figure 5

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Figure Caption

Figure 5

Database analyses of SHOX-regulated genes. (A) Network-based pathway analysis of SHOX-regulated genes using the Ingenuity pathway analysis (IPA) software. SHOX is highlighted in red. Known SHOX-associated genes are shown in yellow. Novel SHOX-regulated genes are shown in gray. Direct regulations are indicated by arrows and interactions as lines; indirect regulations or interactions are presented as dotted arrows/lines, respectively. The most important annotated pathways relevant to SHOX-associated diseases or function are highlighted in green (genes involved in growth failure and short stature) and blue (genes involved in limb defects). (B) Gene-disease association according to DisGeNET. Venn diagram showing associations between SHOX and 23 SHOX-regulated genes with respect to skeletal phenotypes based on the DisGeNET database (https://www.disgenet.org/home/; Pinero et al., 2015).

Acknowledgments

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