ZFIN Image: Prajsnar et al., 2020, Fig. 8

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Figure Caption

Fig. 8 Diminished Sqstm1 recruitment to S. aureus in LAP-deficient neutrophils. (A) Confocal photomicrographs of Sqstm1-mediated response at 2 hpi in live control (top panel) and cyba knockdown (bottom panel) lyz:GFP-Sqstm1 embryos infected with mCherry-labeled S. aureus. The images shown are representative of three independent experiments. Scale bars: approximately 10 µm. (B) Quantification of Sqstm1 associations with intracellular S. aureus at 2 hpi within neutrophils of live lyz:GFP-Sqstm1 infected with mCherry-labeled S. aureus. Data are shown as mean ± standard deviation (SD) obtained from three independent experiments. 66 infected neutrophils in 17 control larvae were analyzed. 90 infected neutrophils in 19 cyba knockdown larvae were analyzed. Unpaired two-tailed t-test was used. **** P < 0.0001

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