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FIGURE 3
Antiproliferative effects of different drugs in three trastuzumab‐resistant cell lines. MDA‐MB‐453, HCC1954, and CK‐MB‐1 cells were treated with one anti‐HER2 monoclonal antibody, two chemotherapies, and five tyrosine kinase inhibitors targeting HER2, PI3K, or AKT. These drugs were less effective against the proliferation of CK‐MB‐1 cells than against the other two trastuzumab‐resistant cell lines. HER2, human epidermal growth factor receptor 2; PI3K, phosphoinositide‐3‐kinase
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