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Fig. 2 Zebrafish hyperlipidemia model. As shown in humans, dyslipidemia in zebrafish is similarly induced by either environmental or genetic factors. Environmental factors such as continuous light exposure, chemical treatment, and diet regimens can influence lipid metabolism and predispose to dyslipidemia in zebrafish. In addition, abrogation of genes associated with lipid metabolism such as nr1h3 and apoc2 using genome editing tools or morpholino results in dysregulated lipid metabolism, leading to fatty liver, obesity and lipid accumulation in vasculature and other organs. HID, high-iron diet; HFD, high-fat diet; HCD, high-cholesterol diet.