Figure 4

Figure 4

MOLM-13 cells in zebrafish xenografts and U0126 treatment. Proliferation of MOLM-13 cells in the zebrafish xenograft model with U0126 treatment started from 2 dpf. The zebrafish xenograft embryos were dissociated (control group at 2 dpf and 5 dpf and treatment group at 5 dpf), and labeled leukemia cells were analyzed by ImageXpress Pico. (A) Total MOLM-13 cells in zebrafish xenografts after U0126 treatment (0, 2.5, 5, and 10 µM). (B) Representative images of zebrafish xenografts at 5 dpf with U0126 treatments. Quantitative values were means ± SEM from 4 to 5 independent groups of 3 xenografts in each group. Significance p values were determined as *p ≤ 0.05, **p ≤ 0.01 and ***p ≤ 0.001.