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Fig. 8 Figure 8. Association of pacemaker cell assay for transposase-accessible chromatin (ATAC-seq) peaks with resting heart rate associated single nucleotide polymorphisms.A, Manhattan plot showing association of 335 353 single nucleotide polymorphisms (SNPs) within or ±0.5 kb away from a region syntenic to any mouse ATAC-seq peak with human resting heart rate ascertained from the UK Biobank cohort. Blue line indicates significance threshold of Bonferroni adjusted P value of 0.01 (corresponding to uncorrected P value 1.2×10-8; B) Manhattan plot similar to (A) including 239 SNPs within or ±0.5 kb away from the top 500 differentially accessible (DA) ATAC-seq peaks. Blue line indicates Bonferroni adjusted P value of 0.01 (corresponding to uncorrected P value 4.2×10-5). C, Manhattan plot showing association of SNPs at the ISL1 locus with resting heart rate. The human genomic region syntenic to the mouse Isl1 sinoatrial node enhancer is highlighted. Chr indicates chromosome.