ZFIN Image: Kula-Alwar et al., 2020, Fig. 6

Image

Figure Caption

Fig. 6

Mef2ca^+/⁻mef2cb^−/−adults are viable but small. (A) Weight and standard length (SL) of genotyped three to four month old adult fish were measured and standard weight (K) calculated. Mef2ca^+/⁻;mef2cb^−/− mutant adults had a significantly lower BW and SL compared with their siblings. Graphs show mean ± S.E.M. for pooled data from 2 lays. N for each group shown on bars. One-way ANOVA was performed followed by Dunnett test for multiple comparison. (B–D)Mef2ca^+/⁻;mef2cb^−/−, mef2cb^−/− and siblings at 4 months of age were measured and their heart dissected and imaged (B). Ventricle length (VL) was measured from images from the centre of the bulbous to the apex of the heart (diagram in C). Graph shows mean ± S.E.M. N for each group shown on bars. VL was plotted vs. SL (D). Note that points for mef2ca^+/⁻;mef2cb^−/− mutants fall below the linear regression line. Scale bars = 1 mm.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 470, Kula-Alwar, D., Marber, M.S., Hughes, S.M., Hinits, Y., Mef2c factors are required for early but not late addition of cardiomyocytes to the ventricle, 95-107, Copyright (2020) with permission from Elsevier. Full text @ Dev. Biol.