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Figure 6—figure supplement 2.

ID: ZDB-IMAGE-201216-27
Source: Figures for Veerapathiran et al., 2020

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Figure Caption

Figure 6—figure supplement 2. Role of Lrp5 coreceptor in Wnt3-Fzd1 binding.

(A) Representative FCCS measurement for Wnt3EGFP and Fzd1mApple in regions with no Lrp5 expression (ventral cerebellum). No cross-correlations obtained outside midbrain–hindbrain boundary and dorsal cerebellum indicating role of Lrp5 in Wnt3-Fzd1 interaction. (B) Knocking down lrp5 morpholino resulting in deformed optic tectum (OT) and cerebellum (Ce) of the zebrafish brain. (C) Wnt3EGFP after treatment with negative control lrp5 mismatch MO with five nucleotide substitutions showing normal brain development and (D) retaining cross-correlations between Wnt3EGFP and Fzd1mApple.

Acknowledgments

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