IMAGE

Fig. 1.

ID
ZDB-IMAGE-200910-18
Source
Figures for Oppel et al., 2020
Image
Figure Caption

Fig. 1.

Loss of suz12 in p53/nf1-deficient fish diversifies carcinogenesis. (A) CRISPR-Cas9-mediated targeting truncates Suz12a and Suz12b proteins before their functional domains, conferring a loss of function. VEFS, VRN2-EMF2-FIS2-SUZ12 domain; WDB, WD-40 binding domain; Zn, Zn-finger region. (B) p53/nf1/suz12-deficient fish are prone to tumors in various anatomical locations, e.g. the abdomen or head (arrows). (C) Histopathology analysis reveals a variety of cancer types in p53/nf1/suz12-deficient tumor-bearing fish, whereas p53/nf1-deficient control fish solely develop MPNSTs. Numbers underneath representative images indicate the frequency of the respective tumor type in nf1a+/− or nf1+/+ tumor-bearing fish analyzed by histology. Scale bars: 100 µm.

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.