ZFIN Image: Ito et al., 2020, Figure 3

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Figure Caption

Figure 3

Drug-mediated inhibition of homomeric and heteromeric zebrafish GlyRs. (a) A recording from a zGlyRα1-injected oocyte exposed to 200 µM glycine with increasing amounts of niflumic acid. (b) Cumulative concentration-dependent inhibition of GlyRα1 current by strychnine, picrotoxin, nifedipine and niflumic acid (n = 10 each). (c) A recording from an oocyte, which were injected with zGlyRα1 and zGlyRβb and exposed to 200 µM glycine with increasing amounts of niflumic acid. (d) Cumulative concentration-curves of strychnine, picrotoxin, nifedipine and niflumic acid-mediated inhibition of α1/βb heteromeric zebrafish GlyRs (n = 10 each).

Acknowledgments

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