ZFIN Image: Labusch et al., 2020, FIGURE 4

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Figure Caption

FIGURE 4

Long-term NSC and neurogenesis dynamic in the adult zebrafish pallium. (A,B) Genetic clonal analysis driven by the her4:ERT2CreERT2 transgene with chase time over 500 days. The number of NSCs per clone containing at least one Sox2+ cell (A) and the proportion of clones containing at least one Sox2+ cell (B) display a bi-phasic dynamics at long term. At early time points after induction, neutral drift is observed -red-. At later time points, a behavior characteristic of single cell-based self-renewal appears -blue-. These two dynamics reflect the behavior of two embedded populations (operational and reservoir, respectively). (C) Total number of Sox2+ cells in the adult Dm between 3 and 25 months post-fertilization (mpf). The Sox2+ population increases in size in the young adult (3–8 mpf), reflecting the NSC-generating activity of a “source” population (orange). (D) Schematic of the proliferative hierarchy of NSC sub-populations sustaining overall NSC maintenance in Dm. Color code as in (A–C) (Than-Trong et al., 2020).

Acknowledgments

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