ZFIN Image: Taler et al., 2019, Fig. 9

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Figure Caption

Fig. 9 col4a5^s510 embryos show the same TGFβ-driven lens phenotype as plod3 mutants. (A,B) Live 4 dpf normal (A) and col4a5^s510/s510 (B) embryos. (n > 100 embryos). (C,D) Transverse histological sections of eyes from 3.5 dpf normal (C) and col4a5^s510/s510 (D) embryos. (n = 10 eyes from each genotype). (E,F) Live 4 dpf normal (E) (n = 6) and col4a5^s510/s510 (F) (n = 5) embryos, treated with SB-431542 from 30 hpf. (G,H) Transverse histological sections from eyes of the same normal and mutant embryos in G and H, respectively. Numbers of eyes analyzed: G = 12, H = 9. A,B,E,F are dorsal views, anterior to left, arrows point at lenses. Scale bars in A,B,E,F are 100 μm and in C,D,G,H 20 μm.

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Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 458(2), Taler, K., Weiss, O., Rotem, S., Rubinstein, A.M., Seritrakul, P., Gross, J.M., Inbal, A., Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate, 177-188, Copyright (2019) with permission from Elsevier. Full text @ Dev. Biol.