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Figure 1
Patient-derived Avatars. Patient-derived cells are used to generate in vitro and in vivo Avatars. In vitro models include spheroids from dissociated tissue; explants, that are not dissociated and retain the original tissue architecture; and organoids, derived from adult stem cells. In vivo models include genetically engineered drosophila flies that mimic patient mutations; and patient-derived mouse or zebrafish xenografts. Zebrafish can be used at the larval or adult stage.
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