Figure 7

Figure 7

Grna; Grnb deficiency mimics the phenotype of the decrease in oligodendrogenesis observed during aging in the adult zebrafish telencephalon. (a) Experimental scheme. (b) Schematic of a typical section from the adult zebrafish telencephalon. Orange area: parenchymal area analysed in the experiment. (c–e″) Micrographs depicting BrdU positive oligodendroglial cells stained with Sox10 (green). (c″–e″) Magnifications with orthogonal projections of boxed areas in (c′–e′), respectively. Yellow arrows depict cells positive for Sox10 and BrdU. Scale bars: 100 µm in (c–e′) and 20 µm in (c″–e″). (f) Histogram depicting the density of BrdU⁺ Sox10⁺ cells in the parenchyma. n.s, not significant, *** p ≤ 0.001, each data point represents a distinct biological replicate (four telencephali per group were analysed).