ZFIN Image: Stratman et al., 2020, Fig. 6

Image

Figure Caption

Fig. 6 Proposed model for inhibition of tumor growth with anti-VEGF versus anti-PI recycling therapies.

a Currently available anti-angiogenic therapies targeting VEGF lead to an initial decrease in tumor growth and angiogenesis. However, production of high levels of pro-angiogenic ligands by tumors results in a relapse in vascular impairment and return of tumor growth. b Our results indicate that targeting PI recycling leads to reduced tumor vasculature and tumor growth, and further suggest that the effects on tumor angiogenesis and tumor growth may be strengthened, not overcome, as tumor production of VEGFA and/or other cytokines increases.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.