ZFIN Image: Burrows et al., 2020, Fig. 4

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Figure Caption

Fig. 4 Increases in neural whole-brain neuronal synchrony during PTZ-induced seizures.

(A) Example normalised fluorescence traces are shown as whole brain mean traces and examples of individual neurons at baseline (black) and PTZ-induced seizure (red) conditions (note the difference in amplitude scale). (B) Map of individual cell firing probabilities across the two conditions demonstrates an increase in firing probability in the PTZ-induced seizure condition, with regional heterogeneity across the larval fish brain. (C) Between-region functional connectivity shown as correlation matrix. Segmented cells were registered to a zebrafish brain atlas and then averaged, to measure correlation between major brain regions (>70) across baseline and PTZ conditions. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Eur. J. Paediatr. Neurol.