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Yang et al., 2019 - Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model

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Figure 7

Validation of microarray with qPCR for the representative genes. Expression of (A,F) scd, (B,G) gck, (C,H) acat2, (D,I) pik3ca, and (E,J) aldh7a1 in WT, HBx(p53-), Src(p53-), and HBx,Src(p53-) fish after eight weeks of normal diet (NOR), overfeeding (diet-induced obesity, DIO), or high-fat diet (FAT) from (A–E) microarray and (F–J) qPCR analysis. (K) Top 14 genes selected by global omics data analysis. (L) Among the 14 genes, 5 genes (red) overexpressed in WT diet-induced obesity are related to glucose and lipid metabolism. The number of fish is 20 for each group, and the number of experimental replicates for qPCR analysis is 3.

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