ZFIN Image: Joseph et al., 2018, Figure 1

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Figure Caption

Figure 1

The N-Terminal Region of CEP120 Contains Three C2 Domains, the Second of Which Is Targeted by JS (V194A) and JATD (A199P) Mutations

(A) Domain organization of human CEP120 protein. cc, coiled-coil domain. C2A,C2B,C2C, first, second, third C2 domain. Shown below are ribbon representations of the corresponding C2 domain structures from Danio rerio (C2A), O.n. (C2B), and Mus musculus (C2C), colored in rainbow from the N-terminus to the C-terminus. Successive β strands in the C2 domains are labeled from β1 to β8.

(B) Close-up view of the regions of C2B (boxed in A) targeted by the V195A (human V194A) and A200P (human A199P) mutation. Side chains in the vicinity of V195 and A200 are labeled and shown as sticks.

(C) Left: ribbon representation of a superposition of the WT (green) and A200P (red) O.n. C2B structure (A199P in human CEP120). Right: close-up view of the region boxed on the left. Residues surrounding A200/P200 are indicated by sticks and are labeled.

See also Figures S1 and S2 and Tables S1–S3.

Acknowledgments

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