ZFIN Image: Olson et al., 2018, Figure 5

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Figure 5

Signaling pathways for rosette formation and proto-NM maturation. (A) Hypothesized signaling that initiates apical constriction. Fgf signaling activates Ras and MAPK. This initiates transcription of schroom3. Schroom3 interacts with Rock 2a (Rho Kinase) and activates non-muscle myosin at the membrane, which initiates apical constriction of cells through reorganization of the actin cytoskeleton. (B) proto-NM maturation signaling. Fgf luminal signaling initiates atoh1a and notch3 expression. Atoh1a induces expression of deltaA and fgf10a. DeltaA interaction with Notch3 initiates lateral inhibition allowing for atoh1a expression to be localized to the central cell (hair cell precursor) and surrounding cells to remain as supporting cells.

Acknowledgments

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