Figure 4

Figure 4

Signaling and chemotactic pathways active during pLLP migration. (A) Signaling pathways active during pLLP migration. Wnt signaling is active in the leading region (blue and green cells). Wnt signaling initiates expression of Fgf3/10a in the leading cells. Fgf 3/10a activate Fgf signaling in the trailing region (orange). Wnt signaling initiates expression of sef , an inhibitor of Fgf signaling. Fgf signaling initiates expression of dkk1 and dkk2, inhibitors of Wnt signaling. Thus the two signaling regions are maintained through mutual inhibition. (B) Chemokine signaling during pLLP migration. Green strip indicates the internal Cxlc12a generated within the pLLP. cxcr4b chemokine receptor (yellow) is expressed in the leading 2/3 of the pLLP. cxcr7b is expressed in the trailing 1/3 of the pLLP (purple).