ZFIN Image: Moore et al., 2012, Figure 3

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Figure 3

Syngeneic zebrafish transplant models of T-ALL are a powerful tool for drug discovery: T-ALL growth is suppressed by cyclophosphamide treatment. Approximately 200 cells/5 nL were engrafted into 5-day-old syngeneic CG2  larvae. Engrafted animals were treated with cyclophosphamide (400 mg/L dissolved in fish water) beginning 5 days posttransplantation. Images of control (a) and treated animals. (b) Tumor growth was assessed based on the percentage of body taken over by GFP+ T-ALL and compared using t-test calculations. This work was performed in [31] and later published in [61].

Acknowledgments

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