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Fig. 3
The ZMEL/Casper Transplant Assay Allows for Single-Cell Resolution of the Entire Metastatic Cascade
(A) The ZMEL1 line is derived from a transgenic zebrafish melanoma. It is then transplanted into the skin of the transparent casper recipient.
(B) Tumors initiate at a defined spot where cells are injected (blue arrow) and metastases (red arrows) can then be followed over time.
(C) An example of a single extravasating ZMEL1-GFP cell at a distant site show its appearance while still in the blood vessel (marked by an flk-RFP transgene) and immediately after extravasation out of the blood vessel.
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Reprinted from Developmental Cell, 49, Cagan, R.L., Zon, L.I., White, R.M., Modeling Cancer with Flies and Fish, 317-324, Copyright (2019) with permission from Elsevier. Full text @ Dev. Cell