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Fig. 3
TEM analysis confirms degeneration of the RPE, photoreceptors, and Bruch’s Membrane.
(A,B) TEM images of unablated 8dpf and (C,D) 3dpi eyes. Compared to unablated controls, the ONL and RPE is degenerated in ablated larvae, with large aggregates of debris notable in the RPE (C, arrow). Magnified views of BM reveal reduced BM thickness as well as obvious gaps (D, arrows). (E) Quantification of BM thickness reveals a significant reduction in BM thickness in ablated larvae (Student’s T-test, MTZ- n = 3 eyes, MTZ+ n = 4 eyes p<0.0001).
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