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Fig. 4
Gross morphological changes in the zebrafish larvae following anti-angiogenic compound exposure at 120 hpf. Wild-type zebrafish were collected at 6 hpf and were treated with bevacizumab (28 ng, 83 ng and 250 ng per embryo), endostar (11 ng, 33 ng and 99 ng per embryo) and apatinib (0.22 μg/mL, 0.67 μg/mL and 2 μg/mL dissolved in breeding water) at 28 °C until 120 hpf. Apatinib (0.67 µg/mL) treatment: pericardial edema (arrow); apatinib (2 µg/mL) treatment: pericardial edema (arrow), decreased eye size (arrowhead) and shortened body axis.
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