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Fig. 3-S2
Dorsomorphin does not rescue MEK-inhibitor-induced endothelial expansion.
Embryos were treated at bud stage with dorsomorphin and a subset of them were assayed at the 12-somite stage for the loss of pSMAD 1/5/8 staining in the tailbud (A, B, arrow indicates loss of pSMAD staining, red color is DAPI staining). (C–F) A subset of the remaining embryos were treated at the 12-somite stage with the MEK inhibitor, fixed 6 hr later and stained for mRNA expression of the endothelial marker etv2. Dorsomorphin did not rescue MEK-inhibitor-induced expansion of endothelium (F compared to E).
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