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Fig. 4
Phagosomes accumulate following treatment with PI3K/Akt/mTor inhibitors. (a) Accumulation of phagosomes, which are packets of shed ROS that can be detected with Rhodopsin immunolabeling, following disrupted RPE phagocytosis or digestion. (b) Signaling pathways targeted by compounds that resulted in phagosome accumulation. (c) Compounds that target the PI3K/Akt/mTor pathway lead to phagosome accumulation as compared to the DMSO control. Merged images show GFP-expressing rods in green, HA-mCherryTM stripe in red, and Rhodopsin immunolabeling in blue. Scale bar is 10 μm.
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