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Fig. 5
Eaf1 and eaf2 obviously suppressed axin2 expression. (A) Eaf1 and eaf2 suppressed axin2 promoter activity induced by β-catenin2 (A2) but not by β-catenin1 (A1). (B) Expression of axin2 was obviously abolished in the dorsal domain of eaf1/2 gain-of-function embryos. (C) Expression of axin2 was obviously abolished in both dorsal and ventral regions of embryos injected with Wnt antagonist frzb or dntcf. B1-B3, C1-C3, animal view, dorsal to the right; B4-B6, lateral view, dorsal to the right.
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