Image
|
Figure Caption
Fig. 1
Alterations in RA affect craniofacial structures. Treatment of adult zebrafish with 100 nM RA (C) for 5 days caused a prognathic jaw (black arrow) and increased distance from the eye to the gill (blue line) as compared to untreated (A) and 0.1% DMSO control–treated (B) fish. Inhibition of RA synthesis through treatment with the pan–aldehyde dehydrogenase inhibitor DEAB (10 μM) for 5 days (D) decreased the height of the head (red line) and caused cataract formation (white arrow). Treatment with RA or DEAB did not affect the jaw length (green line, [A]) or horizontal (anterior to posterior) diameter of the cornea (yellow line, [A]).
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Invest. Ophthalmol. Vis. Sci.