ZFIN Image: Vargo et al., 2017, Fig. 3

Image

Figure Caption

Fig. 3

Mdivi-1 protects against cisplatin-induced hair cell death. (A) Concentrations of mitochondrial division inhibitor mdivi-1 between 1–5 μM are well tolerated by zebrafish; whereas 10 μM of mdivi-1 is toxic to hair cells (n = 5 larvae per data point, from three clutches). (B) Application of 3 or 7 μM of mdivi-1 allowed significantly more hair cells to survive treatment with 50 and 100 μM of cisplatin. (C) Representative maximum-intensity projection images of pvalb3b::GFP neuromast hair cells treated with 50-μM-cisplatin and/or 50-μM-mdivi-1 (middle and right images). Data are mean, error bars indicate SEM. **p < 0.001 and *p < 0.05, in comparison to no mdivi-1 treatment within the same cisplatin concentration (see Supplementary Table S1). Scale bar: 10 μm.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.