ZFIN Image: Schoppik et al., 2017, Fig. 6

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Fig. 6

The simplified neural circuit underlying the ocular response to pitch and roll tilts. Cyan represents nose-down. Magenta represents nose-up channels. A, Wiring diagram of one hemisphere of the excitatory vestibulo-ocular circuit showing utricular hair cells (cyan/magenta), stato-acoustic ganglion (SAG), central vestibular neurons (VN, cyan and magenta), extraocular motoneuron pools in nIII (SR, IR, IO) and nIV (SO). B, During a roll tilt to the fish's left, the left utricle hair cells (cyan/magenta) are activated, causing cocontraction of superior (SO/SR) eye muscles ipsilateral to the activated utricle, and inferior (IO/IR) muscles contralateral to the activated utricle. C, Utricular hair cells sensitive to nose-up pitch tilts (magenta) ultimately activate only vestibular neurons that project to both nIII and nIV, activating SO (contralateral) and IR (ipsilateral). D, Utricular hair cells sensitive to nose-down pitch tilts (cyan) ultimately activate vestibular neurons that project to exclusively to nIII, activating SR (contralateral) and IO (ipsilateral).

Acknowledgments

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