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Fig. 3
Nup210 Depletion Inhibits Myofibrillogenesis and Results in Muscle Cell Death
(A) Thin filament structure in control and Nup210 morphants was analyzed by phalloidin staining at different times of development.
(B) Tail muscle was stained for apoptotic death with an anti-activated caspase-3 antibody in control and Nup210-depleted animals.
(C) Cross-sections of zebrafish animals at 96 hpf were stained with the slow muscle marker F59 (green), phalloidin (red), and DAPI (blue) (n = 6–10 embryos).
Representative images of n ≥ 3 independent experiments. n = 10–20 embryos unless otherwise specified. Scale bars, 50 μm.
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Reprinted from Developmental Cell, 41, Raices, M., Bukata, L., Sakuma, S., Borlido, J., Hernandez, L.S., Hart, D.O., D'Angelo, M.A., Nuclear Pores Regulate Muscle Development and Maintenance by Assembling a Localized Mef2C Complex, 540-554.e7, Copyright (2017) with permission from Elsevier. Full text @ Dev. Cell