ZFIN Image: Demy et al., 2017, Fig. 4

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Figure Caption

Fig. 4

The basal migration in interstitial tissues of both macrophages and neutrophils is affected in moonshine mutants. In vivo 4D tracking of mCherry-positive macrophages and GFP-positive neutrophils in the head and anterior yolk sac area of mon^NQ039Tg(mpeg1:mCherryF; mpx:gfp) sibling (Sib) (A–A″) and mutant (Mut) (B–B″) embryos at 48 hpf. e, ear; l, lens; y, yolk sac; h, hindbrain; r, retina. Cell trajectories are shown in panels (A′,A″,B′,B″), with colour coding of speed (from 0 to 300 µm/h), and the number (Nb) of cells tracked per time point in each case is shown in C (as mean±s.d. for 80 time points). (D,E) Quantification of the mean±s.d. square displacement over time illustrates the migration defect of the mutant leukocytes.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.