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Fig. S4
Early tumorigenesis caused by constitutive activation of kRASG12V. Constitutive activation was induced at 1dpf and representative fish showed early tumorigenesis at 5dpf (A-C) and 3dpf (D, E). Notice the hyperplasic tissue (shown by an arrow in B, C), which displayed upon H&E staining a pack of cells with condensed nuclei and an increased nuclei/cytoplasm ratio characteristic of tumors. Scale bar: 200 μm.
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