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Fig. S5

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Publication: Madigan et al., 2017 - A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy
All Figures: Figures for Madigan et al., 2017

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Fig. S5

Nitric Oxide Production in Infected Macrophages, Related to Figure 6

(A) Mean (±SEM) fold change of Nos2 (iNOS) transcript in WT murine macrophages, 6 hr after infection with WT M. marinum or M. marinum:PGL-1 (both MOI 1), compared to uninfected cells. (Average of 3 independent experiments; Student’s t test).

(B) Representative confocal images of a macrophage aggregate in an mpeg1 larva infected with M. leprae and stained with α-iNOS antibody. 10 μm bar.

(C) Representative confocal images of a macrophage aggregate in an mpeg1 larva infected with M. marinum:PGL-1 and stained with α-iNOS antibody. 10 μm bar.

(D) Representative confocal images of a macrophage aggregate in larvae as in C, stained with α-nitrotyrosine antibody. 10 μm bar.

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Reprinted from Cell, 170, Madigan, C.A., Cambier, C.J., Kelly-Scumpia, K.M., Scumpia, P.O., Cheng, T.Y., Zailaa, J., Bloom, B.R., Moody, D.B., Smale, S.T., Sagasti, A., Modlin, R.L., Ramakrishnan, L., A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy, 973-985.e10, Copyright (2017) with permission from Elsevier. Full text @ Cell