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Fig. 5
Inhibition of calcineurin (FK506-treatment) increases cx43 and reduces the frequency of evx1-positive rays. A: Whole-mount ISH shows increased cx43 and decreased evx1 expression at the time of joint initiation (87 hpa) in FK506-treated fish vs. DMSO (negative control). B: FK506-treated fish (n = 3 fins) showed reduced frequency of evx1-positive fin rays compared to DMSO-treated fish (n = 4 fins). Statistically significant differences were determined by the Student's t-test, where P < 0.01 (**). Error bars represent the standard deviation.
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