ZFIN Image: Chen et al., 2017, Fig. 4

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Figure Caption

Fig. 4

Morphological changes caused by GUCA1A p.R120L. (a) Light microscopy indicates no evident morphological changes in eyes of zebrafish injected with GUCA1A^WT, or GUCA1A^p.R120L, or GUCA1A^WT+p.R120L 4 days postfertilization (dpf). (b–e) Transmission electron microscopy of the retina of zebrafish 11 dpf injected with GUCA1A^WT or GUCA1A^p.R120L. Photoreceptors are regularly lined and shaped in the GUCA1A^WT-injected group (b, d). Thickness of the RPE; shrinking, twisty, and caducous photoreceptor outer segments; and choriocapillary disruptions are found in the GUCA1A^p.R120L-injected group (c, e). ▵ represents the RPE nucleus. Scale bar = 1 μm.

Acknowledgments

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