IMAGE

Fig. 2

ID

ZDB-IMAGE-170523-7

Genes

pxna
pxnb

Antibodies

Ab1-pxn

Source

Figures for Jacob et al., 2017

Image

Figure Caption

Fig. 2

Double Paxillin mutant zebrafish embryos develop gross morphological defects. (A-H) Gross morphology of wild-type (A), homozygous zygotic single pxn mutant (B, C), maternal and zygotic (MZ) single pxn mutant (D, E), zygotic double pxn mutant (F) and MZ double pxn mutant (G, H) embryos at 4 dpf. Defects in double mutants included pericardial edema (arrows in F, G, H), and kinked tail (arrowhead in G). (I) Western blotting of lysates from 4 dpf embryos revealed that double pxn mutants lacked full-length Pxna and Pxnb proteins, including a high molecular weight band possibly corresponding to the Pxnb-ins isoform.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 425(1), Jacob, A.E., Amack, J.D., Turner, C.E., Paxillin Genes and Actomyosin Contractility Regulate Myotome Morphogenesis in Zebrafish, 70-84, Copyright (2017) with permission from Elsevier. Full text @ Dev. Biol.