|ZFIN ID: ZDB-IMAGE-170502-9|
Overexpression of Gab2wt increases the number of MYCN–induced hyperplastic neuroblasts in the interrenal gland (IRG). Related to Figure 4
(A) Sagittal sections through the IRGs of MYCN and MYCN;Gab2wt transgenic fish at 5 wpf (dorsal up, anterior left). GFP, green; DAPI, blue; Merge, combined green and blue. GFP+ hyperplastic neuroblasts were indicated by brackets. Dotted lines indicate the head-kidney (HK) boundary. Wpf, weeks postfertilization. Scale bar, 20 μm.
(B) Numbers of GFP+ sympathetic neuroblasts in the IRG regions of MYCN and MYCN;Gab2wt transgenic fish at 5 wpf. Mean values (horizontal bars) were compared by Welch t-test (two-tailed). GFP+ cell numbers are significantly increased in the MYCN;Gab2wt fish as compared to those in the MYCN-only fish.
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