ZFIN Image: Ki et al., 2017, Fig. 5

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Fig. 5

Sunitinib retards the progression of primary MPNSTs in transgenic fish with wild-type PDGFRA. (a–f) Images of Tg (sox10:PDGFRA wild-type; sox10:mCherry; nf1a^+/−; nf1b^−/−; p53^m/m) zebrafish with primary MPNSTs before drug treatment. mCherry driven by the sox10 promoter is expressed by the tumor cells. Fish with MPNSTs were incubated in 2 μm of sunitinib (n=3) or DMSO (n=3) in the fish water for 10 days. (g–l) After drug treatment, tumor images were taken under the same condition as before treatment. (m) Comparison of cross-sectional areas of MPNSTs after sunitinib treatment and the DMSO control shows that the tumors increase in size when treated with the DMSO vehicle, and that this growth appears to be retarded by sunitinib treatment (P<0.05).

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Acknowledgments

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