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Fig. S5
Effect of Artemether on Pancreatic Islets In Vivo, Related to Figure 5
(A) Islet morphology and GFP expression as marker of α cells of Tg(Gcga:GFP)ia1 zebrafish larvae treated from 26 hpf until 100 hpf with artemether.
(B) Quantification of Glucagon-GFP positive cells and Insulin-mCherry positive cells per single zebrafish islets (8-10 fish per condition; ∗p = 0.007, ∗∗p = 0.088, ∗∗∗p = 0.004, ∗∗∗∗p = 0.003). Error bars represent mean ± SD.
(C) Immunofluorescence for Sst, Pp, and BrdU co-stained with insulin or glucagon in mouse pancreas with or without artemether treatment.
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Reprinted from Cell, 168(1-2), Li, J., Casteels, T., Frogne, T., Ingvorsen, C., Honoré, C., Courtney, M., Huber, K.V., Schmitner, N., Kimmel, R.A., Romanov, R.A., Sturtzel, C., Lardeau, C.H., Klughammer, J., Farlik, M., Sdelci, S., Vieira, A., Avolio, F., Briand, F., Baburin, I., Májek, P., Pauler, F.M., Penz, T., Stukalov, A., Gridling, M., Parapatics, K., Barbieux, C., Berishvili, E., Spittler, A., Colinge, J., Bennett, K.L., Hering, S., Sulpice, T., Bock, C., Distel, M., Harkany, T., Meyer, D., Superti-Furga, G., Collombat, P., Hecksher-Sørensen, J., Kubicek, S., Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity., 86-100.e15, Copyright (2017) with permission from Elsevier. Full text @ Cell