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Fig. S5

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ZDB-IMAGE-170209-23
Source
Figures for Barske et al., 2016
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Figure Caption

Fig. S5

Independently derived prrx1a; prrx1b mutants confirm specificity of skeletal phenotype.

(A, B) Independently derived prrx1ab1246; prrx1bb1247 double mutants (B, B') phenocopy prrx1ael558; prrx1bel491 mutants (Fig 7B). Note the expanded cartilage in the palatoquadrate (black arrowhead) and the fusions between the hyomandibula and otic cartilage (black arrow). Scale bar = 100 μm. (C) Schematic of prrx1a/b TALEN (el558, el491) and CRISPR (b1246, b1247) alleles. In all cases, the mutant allele produces a frameshift (black) and premature stop codon upstream of the homeobox (Hx) and OAR domains (O).

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