ZFIN Image: Ellis et al., 2016, Fig. 8

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Fig. 8

Morpholino knock-down of the aryl hydrocarbon receptor rescues some but not all effects of PhN treatment. Tg(fli1:eGFP) embryos were injected with morpholinos demonstrated to interfere with the expression of AhR2, thereby protecting them from PAH-toxicity, or control morpholinos, and were then exposed to 10 µM PhN from 24 to 48 hpf. (A) Control morphants exhibit typical PAH toxicity effects (tail curvature, necrosis, pericardial and yolk-sac edema), as well as disrupted angiogenesis, loss of pigmentation, and craniofacial defects; (B) Ahr2 morphants exhibit reduced pericardial and yolk-sac edema, but still exhibit loss of pigmentation, craniofacial defects; and (C) disrupted angiogenesis.

Acknowledgments

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