ZFIN Image: Ji et al., 2016, Fig. 3

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Figure Caption

Fig. 3

Pitx2HD mutants grow to adulthood and develop eye defects. (A) Normal gross appearance of wild-type, pitx2HD^sny7/sny7 and pitx2c^sny3/sny3 fish at 5 dpf. (B) Homozygous pitx2HD mutants reached adulthood, but were smaller than heterozygous siblings and had malformed eyes (arrow). Adult homozygous pitx2c mutants were indistinguishable from wild-type siblings. (C) Eye and craniofacial phenotypes in adult fish. Ocular defects of the iris and cornea (arrow) were observed in pitx2HD mutants, but not pitx2c mutants.

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Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 416(1), Ji, Y., Buel, S.M., Amack, J.D., Mutations in zebrafish pitx2 model congenital malformations in Axenfeld-Rieger syndrome but do not disrupt left-right placement of visceral organs, 69-81, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.