ZFIN Image: McCarthy et al., 2016, Fig. 3

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Figure Caption

Fig. 3

The zebrafish postchordal neurocranium is derived from both mesoderm and neural crest tissues. (A-F) Confocal images of 5 days post-fertilization flatmounted zebrafish neurocrania of (A and B) sox10:KikGR, (C and D) sox10:Cre;ubiRSG, and (E and F) drl:CreERT2;ubi:switch. Anterior is to the left. In C and D the red and green channels have been switched for clarity in comparisons to A and B. (B, D and F) Lineage-traced cells only, neurocrania outlined in white. (A-D) Neural crest contributes to the prechordal elements the ethmoid plate and trabeculae, as well as the lateral and anterior regions of the anterior basicapsular commissures and the lateral auditory capsules. (E and F) Mesoderm contributes the parachordals, anterior and posterior basicapsular commissure, the occipital arch, and the lateral commissures. Schematic of results shown in G (ne10 for each transgenic line). abc-anterior basicapsular commissure, ac-auditory capsule, ep-ethmoid plate, lc-lateral commissure, n-notochord, oc-occipital arch, pbc-posterior basicapsular commissure, pc-parachordals, tr-trabeculae. scale bar=50 µm.

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Acknowledgments

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Reprinted from Developmental Biology, 415(2), McCarthy, N., Sidik, A., Bertrand, J.Y., Eberhart, J.K., An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull, 261-77, Copyright (2016) with permission from Elsevier. Full text @ Dev. Biol.