ZFIN Image: Kawase et al., 2016, Fig. 5

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Fig. 5

Inhibition of EP300 reduces the photoreceptor cell outer segments in a zebrafish model of light-induced retinopathy. (A) Protocol for light-induced retinal damage in larval zebrafish, as described for Figure 4A. After light exposure, whole-mount immunohistochemical staining with anti-Zpr3 antibody was performed. (B) Representative images of anti-Zpr3 antibody staining of zebrafish exposed to normal or intense light. Scale bars, 100 µm. (C) Quantitative analysis of photoreceptor cell outer segments of zebrafish exposed to the conditions shown in (B). *p < 0.05. Data are the mean ± SEM of n = 24 zebrafish/group for light-/C646- and light-/C646+, n = 17 for light+/C646-, and n = 22 for light+/C646+.

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Acknowledgments

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