ZFIN Image: Decker et al., 2014, Fig. 3

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Figure Caption

Fig. 3

Dopamine rescues behavioral and fictive locomotor patterns of the trpm7 mutant. (A) (Top row) Representative recordings of speed and (bottom row) extracellular peripheral nerve recordings in fictive swimming preparations for discrete swimming episodes of 5-6 dpf control siblings (left), trpm7 mutants (middle), and trpm7 mutants+DA (20 µM; right). Grey bars below x-axes of speed plots represent episode durations whose beginnings and ends are defined by the filter settings. (B) Summary plot of the mean durations of behavioral and fictive swimming episodes for each group. Asterisks indicate significant difference; ***p<0.001. Numbers at the base of bars in graph denote number of larvae observed for each experimental group. Error bars represent SEM.

Figure Data

Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 386(2), Decker, A.R., McNeill, M.S., Lambert, A.M., Overton, J.D., Chen, Y.C., Lorca, R.A., Johnson, N.A., Brockerhoff, S.E., Mohapatra, D.P., Macarthur, H., Panula, P., Masino, M.A., Runnels, L.W., and Cornell, R.A., Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern, 428-39, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.