ZFIN Image: Powell et al., 2015, Fig. S2

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Figure Caption

Fig. S2

cdonis not required for cranial neural crest migration and cartilage development. (A)–(I) Alcian blue staining of cartilage at 5 dpf shows normal formation of cartilage in uninjected wildtype and cdon morphant embryos. (B), (E), and (H) In a small percentage of cdon morphants, mild hypoplasia was observed as well as (C), (F), and (I) moderate ethmoid plate narrowing. (J), and (K) dlx2a expression, a marker of pharyngeal arch NCCs at 24 hpf is also not affected by cdon knockdown. (L) Embryos were classified by phenotype as exhibiting either normal formation, mild hypoplasia, or narrowing of the ethmoid plate. cdon morphants are mostly normal with a small percentage displaying some mild craniofacial defects.

Acknowledgments

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Reprinted from Developmental Biology, 407(2), Powell, D.R., Williams, J.S., Hernandez-Lagunas, L., Salcedo, E., O'Brien, J.H., Bruk Artinger, K., Cdon promotes neural crest migration by regulating N-cadherin localization, 289-99, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.