ZFIN Image: Karra et al., 2015, Fig. 4

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Figure Caption

Fig. 4

NF-κB has pleiotropic inhibitory effects on heart regeneration. (A–C) Section images of cmlc2:CreER; βact2:BS-gata4, cmlc2:CreER; βact2:RS-IκBSR, and cmlc2:CreER; βact2:BS-gata4; βact2:RS-IκBSR ventricles at 30 dpa after treatment with 4-HT. Images are stained for Tnnt to demarcate cardiac muscle. Dashed line indicates approximate resection plane. (D and E) Tilescan images of cmlc2:CreER; βact2:RS-IκBSR; tcf21:nuceGFP ventricles at 14 dpa after treatment with vehicle or 4-HT. Images are stained for Tnnt to denote cardiac muscle. (F) Quantification of tcf21⁺ cell responses in cmlc2:CreER; βact2:RS-IκBSR hearts treated with vehicle (n = 10) or 4-HT (n = 12) at 14 dpa. Error bars indicate SE. *P < 0.05, Student’s t test, two-tailed. (Scale bars: 100 µm.)

Acknowledgments

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